Dr. Sundeep Khosla is a distinguished endocrinologist and leading authority in skeletal biology at Mayo Clinic where he holds the prestigious Dr. Francis Chucker and Nathan Landow Research Professorship of Medicine and Physiology and serves as a Mayo Foundation Distinguished Investigator. After earning his A.B. degree summa cum laude from Harvard College in 1978 and his M.D. cum laude from Harvard Medical School in 1982, he completed his residency in Internal Medicine and fellowship in Endocrinology at Massachusetts General Hospital. In 1988, he joined Mayo Clinic where he established the Osteoporosis and Bone Biology Laboratory, building a world-renowned research program focused on fundamental mechanisms of skeletal aging. Dr. Khosla currently directs the Mayo Clinic Center for Clinical and Translational Science, demonstrating his leadership in advancing translational research methodologies across multiple disciplines. His distinguished career spans over three decades of continuous contributions to understanding the biological basis of age-related bone disorders.
Dr. Khosla's pioneering research has fundamentally transformed our understanding of age-related bone loss through his groundbreaking investigations into cellular senescence as a key mechanism driving osteoporosis. His laboratory developed innovative genetic models for the targeted clearance of senescent cells globally and in tissue-specific contexts, providing critical tools for studying skeletal aging and potential therapeutic interventions. By applying single-cell proteomic and transcriptomic approaches, his team has identified specific senescent cell populations within the bone microenvironment and elucidated their complex interactions with immune cells, revealing novel pathways for therapeutic intervention. His translational research has successfully bridged preclinical findings to early-phase clinical trials of senolytics, compounds that selectively eliminate senescent cells, offering promising new approaches to combat age-related bone loss and improve skeletal health in older adults. Dr. Khosla's work on the systemic interplay between the aging skeleton and other tissues including muscle, fat and brain has established a new paradigm for understanding skeletal aging and related comorbidities.
Beyond his laboratory discoveries, Dr. Khosla serves as Editor-in-Chief of the prestigious journal Bone and has held editorial positions with the Journal of Bone and Mineral Research, Journal of Clinical Investigation, and other leading publications, shaping the direction of skeletal research worldwide. His leadership extends to directing major collaborative projects including the Mayo Clinic Center for Clinical and Translational Science, which supports researchers across multiple disciplines in advancing patient-centered discoveries. Dr. Khosla actively mentors the next generation of physician-scientists and has built a robust research program that bridges fundamental mechanisms of aging with clinical applications, training numerous investigators who have gone on to establish independent careers in bone metabolism research. Current research initiatives in his laboratory focus on characterizing senescent cell populations in skeletal aging, investigating cellular senescence in skeletal muscle aging, and defining the interactions between senescent immune cells and skeletal cells, promising further breakthroughs in understanding aging mechanisms. With ongoing investigations into senolytic therapies and their potential to improve physical function and extend healthspan, Dr. Khosla's work continues to position him at the forefront of translational geroscience, with implications that extend far beyond skeletal health to multiple age-related conditions.
