Dr. Richard D. Palmiter is a preeminent cellular biologist whose pioneering work has fundamentally transformed genetic research and biomedical science. He currently serves as Professor of Biochemistry and Genome Sciences at the University of Washington School of Medicine, a position he has held since 1974, and as an Investigator of the Howard Hughes Medical Institute since 1976. Dr. Palmiter earned his Bachelor of Arts in Zoology from Duke University in 1964 followed by a PhD in Biological Sciences from Stanford University in 1968, establishing the foundation for his groundbreaking career in molecular biology. His early research focused on steroid hormone regulation of gene transcription, particularly demonstrating how sex steroids regulate egg white production genes in laying hens, setting the stage for his later revolutionary discoveries.
Dr. Palmiter's most significant contribution was the creation of the first transgenic mice through a landmark fifteen-year collaboration with Dr. Ralph Brinster, resulting in their famous 'super mouse' that grew to twice the normal size due to a growth hormone gene controlled by metallothionein regulatory elements. Published in Nature in 1982, this work represented the first successful introduction and transmission of functional foreign genes into mammalian genomes, fundamentally transforming genetic research methodology worldwide. Their transcontinental collaboration established the foundational techniques for creating transgenic animals across multiple species including mice, rabbits, sheep and pigs, enabling critical discoveries about gene regulation, cell transformation mechanisms, and cancer development. This breakthrough not only demonstrated the feasibility of genetic engineering in mammals but also opened unprecedented avenues for modeling human diseases and testing therapeutic approaches.
Elected to the National Academy of Sciences in 1988 and recipient of the Charles-Leopold Mayer Award in 1994, Dr. Palmiter's influence extends far beyond his laboratory through his mentorship of numerous scientists who have gone on to lead independent research programs. His current research continues to push boundaries as he investigates neural circuits controlling innate behaviors and developing deeper understanding of Parkinson's disease using advanced mouse genetic models and viral gene transfer techniques. Dr. Palmiter's work remains highly influential in both basic and translational research, with applications spanning from agriculture to human therapeutics. His legacy as a pioneer in genetic engineering continues to shape the field of molecular biology and inspire new generations of scientists exploring the frontiers of genetic manipulation and neuroscience.
