Dr. Rémi Buisson is a distinguished molecular biologist whose pioneering work has significantly advanced our understanding of genomic integrity mechanisms and their implications for cancer. He currently serves as Associate Professor of Biological Chemistry in the School of Medicine at the University of California, Irvine where he directs the Buisson Laboratory dedicated to unraveling the complexities of DNA repair and genomic stability. After completing his doctoral studies at Laval University in 2012, he pursued advanced postdoctoral training as a Research Fellow at Massachusetts General Hospital Cancer Center, Harvard Medical School from 2013 to 2018. His exceptional promise was recognized with multiple prestigious fellowships including the Tosteson Postdoctoral Fellowship Award and Susan G. Komen Fellowship which supported his innovative investigations into cancer biology during this formative period.
Dr. Buisson's groundbreaking research has illuminated previously unexplored aspects of cellular transcription and translation regulation in response to DNA damage and viral infections, fundamentally advancing our understanding of genomic instability mechanisms in cancer. His laboratory particularly focuses on the intricate interplay between innate immune responses and transcriptional or translational control pathways during exposure to genotoxic stressors, revealing novel regulatory mechanisms with potential therapeutic implications. With a substantial impact evidenced by over 4,370 citations according to Google Scholar, his seminal work on APOBEC enzymes, DNA damage response, and genome stability has established him as a leading authority in cancer biology. His discovery of previously unrecognized connections between DNA repair pathways and immune system activation has provided critical insights that could transform approaches to cancer treatment. These contributions have positioned his research at the forefront of understanding how genomic instability drives cancer development and progression.
Beyond his research achievements, Dr. Buisson cultivates the next generation of scientific leaders through his dynamic laboratory at UC Irvine which includes postdoctoral fellows, graduate students, and undergraduate researchers all contributing to cutting-edge investigations in genomic stability. As an active member of the Chao Family Comprehensive Cancer Center, he collaborates with clinical researchers to bridge the gap between fundamental genomic discoveries and potential cancer therapeutics. His laboratory continues to pioneer innovative approaches to understanding how cells respond to genomic threats during viral infections and environmental stressors, with the goal of identifying novel targets for cancer prevention. Looking forward, Dr. Buisson's research program aims to further elucidate the complex molecular networks that maintain genome integrity, potentially opening new avenues for precision oncology interventions. His visionary leadership in the field promises to continue driving significant advances in our understanding of cancer biology and genomic stability mechanisms.
