Dr. Marie-Charlotte Domart is a distinguished cell biologist specializing in advanced imaging methodologies at the forefront of cellular visualization research. She serves as a key scientist within the Electron Microscopy Science Technology Platform at the Francis Crick Institute in London, where she applies her expertise to develop innovative correlative microscopy approaches for studying complex cellular processes. With extensive experience in both light and electron microscopy techniques, Dr. Domart has established herself as a leading expert in bridging multiple imaging modalities to reveal cellular structures at unprecedented resolution. Her work continues to advance the field by enabling researchers to observe dynamic biological processes across multiple dimensions with remarkable precision and contextual clarity.
Dr. Domart's groundbreaking contributions include co-developing a comprehensive imaging workflow for 3D correlative light and electron microscopy of cell monolayers, which has revolutionized how scientists investigate autophagy, viral infections, and cellular entosis. Her pivotal 2016 research successfully integrated live imaging with super resolution microscopy techniques to characterize the initiation site of autophagy, uncovering unprecedented details about this critical cellular degradation process. Through her expertise in FIB-SEM and dSTORM microscopy, she has enabled visualization of transient cellular structures that were previously difficult to capture, significantly advancing our understanding of membrane dynamics and protein interactions. Her methodological innovations have been widely adopted by researchers globally, facilitating discoveries in infectious disease mechanisms and cancer biology through enhanced ultrastructural analysis.
As an integral member of the Francis Crick Institute's microscopy platform, Dr. Domart has played a vital role in supporting numerous collaborative research projects that have produced influential publications in high-impact journals. Her technical expertise in correlative imaging methodologies has made her an essential collaborator for research groups investigating complex biological phenomena at multiple scales. The platform she contributes to continues developing cutting-edge imaging technologies including cryo-fluorescence, electron tomography, and integrated light-electron microscopy approaches. Looking ahead, Dr. Domart remains positioned to drive further innovation in cellular imaging as emerging technologies continue to enhance our ability to visualize and understand the intricate machinery of cellular life at ever-finer resolutions.
