Dr. Josef Penninger is a world-renowned molecular biologist whose pioneering work has fundamentally advanced our understanding of genetic mechanisms underlying human disease. Currently serving as Scientific Director of the Helmholtz Centre for Infection Research in Germany since July 2023, he simultaneously holds a Professorship in Precision Medicine at the Medical University of Vienna. An Austrian native born in Gurten in 1964, he completed his medical education at the University of Innsbruck before embarking on a distinguished research career that has spanned North America and Europe. Prior to his current leadership role, he directed the Life Sciences Institute at the University of British Columbia from 2018 to 2023 and founded and led the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences from 2002 to 2018, establishing it as one of the world's premier research centers.
Penninger's groundbreaking research has made seminal contributions across multiple disease areas, most notably identifying the key function of the RANKL gene that controls bone loss in osteoporosis, arthritis, and related conditions, which led to the development of the osteoporosis treatment Denosumab. His laboratory made the critical discovery that ACE2 serves as the cellular receptor for SARS Coronavirus infections, fundamentally transforming our understanding of viral pathogenesis and providing essential insights for therapeutic development during the COVID-19 pandemic. With over 300 peer-reviewed publications, his work has elucidated genetic mechanisms regulating pain, heart disease, circadian rhythms, and lung failure in severe infections, demonstrating his exceptional ability to connect fundamental molecular pathways with clinical applications. His early identification of the genetic basis for osteoporosis and subsequent contributions to understanding viral infection mechanisms represent paradigm-shifting advancements that have directed entire research fields toward new therapeutic targets.
Recognized as one of the world's leading mouse geneticists, Dr. Penninger has received numerous prestigious awards including the Descartes Prize, Ernst Jung Prize in Medicine, and Carus Medal for his transformative research contributions. His leadership extends beyond his laboratory as he continues to shape the global research landscape through his directorship at one of Europe's leading infection research centers, where he oversees critical work on emerging pathogens and potential bioterrorism agents. The asteroid 48801 Penninger stands as a testament to his scientific eminence, honoring his contributions to medical science with a permanent celestial namesake. Currently focusing on infection biology and precision medicine approaches, he is advancing research on novel therapeutic strategies for infectious diseases while mentoring the next generation of scientists who will carry forward his legacy of connecting fundamental genetic discoveries with clinical impact.
