Dr. Hartmut Jaeschke stands as a preeminent figure in toxicological sciences with extensive leadership experience in academic medicine. He currently serves as University Distinguished Professor at the University of Kansas Medical Center, having previously chaired the Department of Pharmacology, Toxicology, and Therapeutics from 2012 to 2024. After earning his PhD in toxicology from the University of Tübingen, Germany in 1983, he completed postdoctoral training at both the University of Tübingen and Baylor College of Medicine in Houston. His distinguished career includes faculty positions at Baylor College of Medicine, significant industry experience at The Upjohn Company and Pharmacia, and professorships at the University of Arkansas for Medical Sciences and the University of Arizona before joining KUMC in 2006.
Dr. Jaeschke's groundbreaking research in liver toxicology and pathophysiology has established him as a world leader in mechanistic toxicology with translational applications. He has authored more than 520 peer-reviewed publications that have accumulated over 62,000 citations and an h-index of 128 according to Google Scholar, reflecting his substantial impact on the field. His work on understanding the mechanisms of drug-induced liver injury has provided critical insights that bridge basic science with clinical applications, significantly advancing the field of translational toxicology. Dr. Jaeschke's research methodology emphasizes the use of clinically relevant concentrations and doses, relevant in vitro systems, and a deep understanding of human disease pathophysiology to ensure meaningful clinical relevance.
As a Fellow of both the Academy of Toxicological Sciences and the American Association for the Study of Liver Diseases, Dr. Jaeschke has profoundly influenced the direction of toxicology research through his leadership roles and scientific contributions. He served as a standing member of the Hepatobiliary Pathophysiology NIH study section from 2008 to 2013 and has contributed to numerous other NIH grant review committees, shaping research priorities in his field. His commitment to translational research has established a framework that emphasizes collaboration with clinicians and investigation of mechanistic aspects of human disease using human cells, organoids, and biopsy tissue. Dr. Jaeschke continues to advance the field through his mentorship of the next generation of toxicologists and his ongoing research that bridges fundamental mechanisms with clinical applications in liver disease.
