Dr. Gregory J. Gores is a distinguished physician-scientist and former Chair of the Division of Gastroenterology and Hepatology at Mayo Clinic in Rochester, Minnesota, where he holds the prestigious Reuben R. Eisenberg Professorship. He currently serves as Editor-in-Chief of Hepatology, the leading journal in liver diseases, a position he assumed for the 2022-2026 term. After earning his medical degree from the University of North Dakota, Dr. Gores completed his fellowship at Mayo Graduate School of Medicine, establishing a career-long affiliation with this renowned institution. His clinical expertise centers on hepatobiliary malignancies, liver transplantation, and mechanisms of liver cell injury, with particular focus on improving outcomes for patients with hepatocellular carcinoma and complex liver conditions. Throughout his tenure at Mayo Clinic, Dr. Gores has held numerous leadership positions that have significantly shaped hepatology research and clinical practice.
Dr. Gores' laboratory-based research program has pioneered fundamental insights into the mechanisms of liver cell death, particularly apoptosis, employing disease-relevant models to unravel cellular processes contributing to liver injury during cholestasis and fatty liver diseases. His sustained federal funding over three decades, encompassing more than 80 projects totaling over $21 million, has generated over 750 publications with an impressive H-index of 156 and more than 79,000 citations according to Scopus data. His work has advanced understanding of how dysregulation of programmed cell death contributes to the development of liver diseases, with particular focus on the role of ferroptosis in biliary tract injury and inflammation. Dr. Gores has developed innovative approaches for early detection of cholangiocarcinoma and contributed to novel protocols regarding liver transplantation for this challenging malignancy, with his fundamental mechanistic insights paving the way for rational pharmacologic approaches to treat inflammatory and malignant hepatobiliary diseases.
Beyond his research contributions, Dr. Gores has profoundly influenced the field through his mentorship of over 80 postdoctoral research and clinical fellows, earning recognition with the American Gastroenterological Association Mentorship Award. His leadership extends to prominent roles including past presidency of the American Association for the Study of Liver Diseases (AASLD) and the International Liver Cancer Association, where he has shaped research agendas and clinical guidelines. Dr. Gores serves as a trusted advisor to the medical community, regularly presenting at national and international academic institutions and contributing to the advancement of hepatology worldwide. His current research continues to explore the cellular and molecular mechanisms underlying liver pathobiology, with ongoing investigations into macrophage-associated inflammation in cholestatic liver diseases. As Editor-in-Chief of Hepatology, Dr. Gores remains at the forefront of the field, guiding scholarly discourse and ensuring the highest standards of research while advancing therapeutic strategies for patients with hepatobiliary disorders.
