Dr. G. Marius Clore is a distinguished molecular biophysicist and structural biologist who serves as an NIH Distinguished Investigator and Chief of the Section of Molecular and Structural Biophysics at the National Institute of Diabetes and Digestive and Kidney Diseases. Born in London in 1955, he earned his BSc with first-class honors in Biochemistry from University College London in 1976 and completed his PhD in Physical Biochemistry at the MRC National Institute for Medical Research in London in 1982. After serving as Head of the Biological NMR Group at the Max Planck Institute for Biochemistry in Germany from 1984 to 1988, he joined the NIH in 1988 as a Senior Investigator, where he has remained for over three decades, advancing to NIH Distinguished Investigator status in 2011. His distinguished career spans both British and American scientific institutions, reflecting his significant contributions to the international structural biology community.
Dr. Clore has pioneered groundbreaking developments in multidimensional nuclear magnetic resonance spectroscopy, playing a pivotal role in creating three- and four-dimensional NMR techniques, residual dipolar couplings for structure determination, and simulated annealing methods for protein and nucleic acid structure analysis. His laboratory has made transformative contributions to understanding the structure, dynamics, and function of proteins, particularly through the development of novel NMR methods to detect, visualize, and characterize transient, sparsely-populated states of macromolecules that are invisible to conventional structural techniques. With over 550 scientific publications and an impressive h-index of 144, his work has fundamentally advanced the fields of molecular biophysics and structural biology, providing critical insights into molecular recognition, allostery, and protein assembly mechanisms. His research on AIDS-related proteins and complexes involved in signal transduction has particularly influenced our understanding of molecular interactions in health and disease.
As a thought leader in structural biology, Dr. Clore serves as Co-Editor-in-Chief of Current Opinions in Structural Biology and has held numerous influential advisory positions including membership on the NIH Intramural AIDS Targeted Antiviral Program Scientific Review Committee and the Executive Committee of the NIH/Oxford/Cambridge Scholars Program. His laboratory continues to innovate at the cutting edge of biophysical methodology, developing new approaches like paramagnetic relaxation enhancement and dark state exchange saturation transfer spectroscopy to visualize short-lived molecular states critical for biological function. Recognized with prestigious honors including election to both the United States National Academy of Sciences and The Royal Society, he ranks among only five NIH scientists to achieve this dual distinction. Dr. Clore's ongoing research promises to further illuminate the dynamic nature of biomolecules, with implications for understanding fundamental biological processes and developing new therapeutic strategies.
