Dr. Donna Mancini is a distinguished cardiologist and leading authority in cardiovascular medicine with a distinguished career spanning over four decades. She currently serves as Professor of Medicine in Cardiology and Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai, where she maintains a prominent clinical and research presence across multiple Mount Sinai hospital campuses. After receiving her MD from Albert Einstein College of Medicine in 1980, she completed her Internal Medicine residency and Cardiology fellowship at Albert Einstein College of Medicine-Yeshiva University, establishing a foundation for her remarkable career in cardiovascular medicine. Dr. Mancini has been instrumental in shaping the Lauder Family Cardiovascular Ambulatory Center at Mount Sinai, providing specialized care for patients with complex cardiac conditions while maintaining strong affiliations with Mount Sinai Morningside, Mount Sinai West, and Mount Sinai Queens. Her clinical expertise encompasses the full spectrum of cardiovascular disease management with a particular focus on advanced heart failure and transplant cardiology.
Dr. Mancini's pioneering clinical research has profoundly influenced the field of heart failure management, with particular expertise in therapies for advanced cardiac conditions and post-transplant care. Her extensive body of scholarly work, comprising over 100 publications with more than 500 citations, has significantly advanced understanding of cardiovascular physiology and metabolism in heart failure patients. Her current research initiatives include cutting-edge investigations into the cardiovascular analysis of post-exertional malaise, supported by substantial NIH funding through 2025, which may transform management approaches for patients with exercise intolerance. The practical impact of her work extends directly to clinical practice, as evidenced by her decades-long specialization in heart failure and transplant cardiology, where she has developed innovative therapeutic strategies that have improved outcomes for thousands of patients.
Beyond her clinical and research achievements, Dr. Mancini has earned recognition as a Castle Connolly Top Doctor for over a decade, consistently appearing in New York Magazine's Top Doctors listings from 2012 through 2025, reflecting her standing among the most respected cardiovascular specialists in the nation. Her election to the prestigious American Society for Clinical Investigation in 1999 marked an early acknowledgment of her scientific contributions to medicine and established her as a thought leader in cardiovascular research. As an active member of the Heart Failure Society of America, she continues to shape professional guidelines and educational initiatives that influence cardiovascular care nationally. Dr. Mancini remains dedicated to advancing the field through ongoing research, mentoring the next generation of cardiologists, and providing exceptional patient-centered care that bridges the latest scientific discoveries with individualized treatment approaches.
