Dr. Danuta Loesch is a distinguished Senior Research Fellow in Psychology at La Trobe University with extensive expertise in neurological disorders and genetic research. Before joining La Trobe University, she built a substantial career as a clinical neurologist, subsequently transitioning into research where she served as a clinician and researcher. Her dual background in clinical neurology and academic research has equipped her with a unique perspective that bridges patient care with scientific investigation, allowing her to address complex neurological conditions with both practical and theoretical approaches. Dr. Loesch has established herself as a respected figure in the field of neurogenetic disorders through her systematic and rigorous research methodology.
Dr. Loesch's research primarily focuses on FMR1 gene disorders, including Fragile X-associated tremor ataxia syndrome and Parkinson disease, where she has made significant contributions to understanding the neurological manifestations of these conditions. Her groundbreaking work examining the relationship between Parkinson Disease Polygenic Risk Score and neurological outcomes in FMR1 premutation carriers has provided critical insights into the genetic underpinnings of movement disorders. She has also investigated the Essential Tremor phenotype in FMR1 premutation and gray zone carriers, expanding our understanding of the neurological spectrum associated with these genetic variations. Dr. Loesch's research has helped establish the concept of a broad FXTAS spectrum, demonstrating that neurological involvement extends beyond traditionally diagnosed cases to include various forms of neurological manifestations.
Through her longitudinal studies and comprehensive neurological assessments conducted over two decades with experienced neurologists, Dr. Loesch has contributed significantly to the diagnostic criteria and understanding of progression in FMR1 related disorders. Her collaborative approach is evident in her international partnerships, including significant work with colleagues at the University of California Davis, reflecting the global impact of her research. Dr. Loesch has served as principal investigator securing research funding and leading projects that have advanced our understanding of the relationship between genetic factors and neurological outcomes. Her ongoing research continues to explore the complex interplay between genetic variations and neurological manifestations, with potential implications for early diagnosis and intervention strategies for individuals with FMR1 gene disorders.
